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Презентация на тему Labmeeting paper. Purkinje cells directly inhibit granule cells in specialized regions of the cerebellar cortex

13.09.2016Portugues Lab meetingDaniil Markov
Papers13.09.2016Portugues Lab meeting 13.09.2016Portugues Lab meetingDaniil Markov 13.09.2016Portugues Lab meetingHypothesis“The IO compares descending motor commands with information about movement and detects mismatches” 13.09.2016Portugues Lab meetingBehavioral paradigm 13.09.2016Portugues Lab meetingAverage discharge rate during different behaviors… is the same. But 13.09.2016Portugues Lab meetingReaching for a missing handleAlmost no discharge related to any 13.09.2016Portugues Lab meetingReaching for a missing handleAlmost no discharge related to any 13.09.2016Portugues Lab meetingResponses to perturbationsDuring stance all cells responded to tapping with 13.09.2016Portugues Lab meetingResponses of rMAO cell to perturbations at different phases of 13.09.2016Portugues Lab meetingOutlookIO cells respond to external stimuli during stance periodThis responsiveness
Слайды презентации

Слайд 2 13.09.2016
Portugues Lab meeting
Daniil Markov

13.09.2016Portugues Lab meetingDaniil Markov

Слайд 3 13.09.2016
Portugues Lab meeting
Hypothesis
“The IO compares descending motor commands

13.09.2016Portugues Lab meetingHypothesis“The IO compares descending motor commands with information about movement and detects mismatches”

with information about movement and detects mismatches”


Слайд 4 13.09.2016
Portugues Lab meeting
Behavioral paradigm

13.09.2016Portugues Lab meetingBehavioral paradigm

Слайд 5 13.09.2016
Portugues Lab meeting
Average discharge rate during different behaviors

13.09.2016Portugues Lab meetingAverage discharge rate during different behaviors… is the same.

is the same. But the average discharge rate is

a bad measure for the IO.

Слайд 6 13.09.2016
Portugues Lab meeting
Reaching for a missing handle

Almost no

13.09.2016Portugues Lab meetingReaching for a missing handleAlmost no discharge related to

discharge related to any particular
phase of the undisturbed

reaching task



No discharge modulation during the multiple attempts to grasp the missing handle



Слайд 7 13.09.2016
Portugues Lab meeting
Reaching for a missing handle
Almost no

13.09.2016Portugues Lab meetingReaching for a missing handleAlmost no discharge related to

discharge related to any particular
phase of the undisturbed

reaching task

No discharge modulation during the multiple attempts to grasp the missing handle

The same cells showed discharge increase when the limb was mechanically stimulated during stance

A mismatch between motor command and expected movement outcome is not sufficient to elicit olivary discharge; stimulation is required.


Слайд 8 13.09.2016
Portugues Lab meeting
Responses to perturbations

During stance all cells

13.09.2016Portugues Lab meetingResponses to perturbationsDuring stance all cells responded to tapping

responded to tapping with probability approaching 100 %
Almost no

discharge related to any particular
phase of the undisturbed reaching task


rDAO cells didn’t respond to unexpected perturbation


PO cells and rMAO cells increased discharge probability after contact with the obstructing bar

Unexpected stimulus, but not the unexpected absence of stimulus, can activate IO cells in some of its subdivisions.


Слайд 9 13.09.2016
Portugues Lab meeting
Responses of rMAO cell to perturbations

13.09.2016Portugues Lab meetingResponses of rMAO cell to perturbations at different phases

at different phases of the task
Responses of some

IO cells to unexpected perturbations depend on the phase of the behavior


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