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Overview
10700 y.a. – The betel nut was chewed
in Thailand
7000 y.a. – Coca was being used
in the Andes
Before European contact – Native Americans used tobacco
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Legality
The resolution of the government of Russian Federation
N 681 (30.06.1998)
1) list I: mescaline and its derivatives,
hashish, heroin, marijuana, methadone, MMDA, opium, psilocybin , psilocin, ephedrine, etc.
2) list II: codeine, cocaine, morphine, ethylmorphine, omnopon, fentanyl, promedol, etc.
3) list III: barbital, nitrazepam, diazepam, taren, etc.
4) list IV:ephedrine, pseudoephedrine, acetone, sulphuric acid, hydrochloric acid, potassium permanganate, acetic acid, etc.
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Mechanisms and effects
Agonists:
increasing the synthesis of one or more neurotransmitters
reducing
its reuptake from the synapses
mimicking the action by binding directly to
the postsynaptic receptor
Antagonists:
interfering with synthesis
blocking postsynaptic receptors
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Addiction
psychological dependence
physical dependence
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Usage
Anxiolytics
Example: Benzodiazepine
Euphoriants
Example: MDMA (Ecstasy), MDA, 6-APB, Indopan
Stimulants ("uppers")
Examples: amphetamine, caffeine, cocaine, nicotine
Depressants ("downers"), including sedatives, hypnotics, and narcotics.
Examples: ethanol (alcoholic beverages), opioids, barbiturates,
benzodiazepines
Hallucinogens, including psychedelics, dissociatives and deliriants
Examples: psilocybin, LSD, Salvia divinorum and nitrous oxide
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Recreation
alcohol –in most areas of the world it is
legal for those over a certain age
tobacco – a legal
drug
cannabis
caffeine - a legal drug, contained in coffee, tea, energy drinsks, and some soft drinks
MDMA
cocaine
amphetamines – prescribed for ADHD
psilocybin mushrooms
LSD –banned in October 1968 by US President Lyndon B Johnson.
opiates and opioids – available by prescription.
tranquilizers – barbiturates, benzodiazepines - commonly prescribed for anxiety
nitrous oxide - legal
ketamine – used by paramedics in emergency situations for its dissociative and analgesic qualities
amyl nitrite – a vasodilator (legal)
other drugs (antidepressants, tranquilizers, analgesics, etc)
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Pharmacoyherapy
Anesthesia
Pain management
Mental disorders
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Depression and Antidepressants
Key facts:
Depression is a common mental
disorder. Globally, more than 350 million people of all
ages suffer from depression
Depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease
More women are affected by depression than men
At its worst, depression can lead to suicide
There are effective treatments for depression
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Drugs used for the treatment of depression:
Selective
serotonin reuptake inhibitors (SSRIs)
Serotonin/norepinephrine reuptake inhibitors (SNRIs)
Atypical antidepressants
Tricyclic antidepressants
(TCAs)
Monoamine oxidase inhibitors (MAOIs)
St. John’s wort ( Hypericum perforatum)
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Selective serotonin reuptake inhibitors, SSRIs
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine
(Prozac)
Paroxetine (Paxil)
Sertraline (Zoloft)
Vilazodone (Viibryd)
Vortioxetine (Brintellix)
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Serotonin/norepinephrine reuptake inhibitors, SNRIs
Desvenlafaxine (Pristiq)
Duloxetine (Cymbalta)
Venlafaxine (Effexor, Effexor
XR)
Levomilnacipran (Fetzima)
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Other Antidepressants
Bupropion (Wellbutrin)
Mirtazapine (Remeron, Remeron SolTab)
Trazodone (Desyrel,
Oleptro)
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Tricyclic antidepressants, TCAs
Amitriptyline (Elavil)
Desipramine (Norpramin)
Imipramine (Tofranil)
Clomipramine (Anafranil)
Nortriptyline (Pamelor)
Protriptyline
(Vivactil)
Doxepin (Sinequan, Silenor)
Trimipramine (Surmontil)
Amoxapine
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Monoamine oxidase inhibitors,MAO Is
Selegiline transdermal patch (Emsam)
Tranylcypromine (Parnate)
Phenelzine
(Nardil)
Isocarboxazid (Marplan)
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Herbals
Hypericum perforatum (St John's Wort)