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Презентация на тему Development of the heart

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2. THE OBJECTIVES:
3. GENERAL PROVISIONS:
4. EARLY DEVELOPMENT OF THE EMBRYO
5. DEVELOPMENT OF THE MESODERM
6. DEVELOPMENT OF THE MESODERM
7. DEVELOPMENT OF THE HEART PRIMODIUMAt first the
8. DEVELOPMENT OF THE PRIMITIVE HEART B
9. DEVELOPMENT OF THE PRIMITIVE HEARTCephalocaudal section showing
10. DEVELOPMENT OF THE PRIMITIVE HEART
11. DEVELOPMENT OF THE HEART23-24 day, as
12. Cells of splanchnic mesodermal layer form the
13. Stage 9 Appearance of Somites 1.5 -
15. The origins of the heart tube are
16. When the neural tube grows it pulls
17. Angiogenic cell clusters which lie in a
18. These angiogenic cell clusters coalesce to form
19. The lateral and cranial folding of the
20. As the single heart tube is being
21. At approximately day 21 the endocardial tubes
23. The single tubular heart develops many constrictions
24. Early Development of the HeartThe newly formed
25. Early Heart Development
26. The original paired cardiac tubes fuse, with
27. The bulboventricular portion of the heart grow
28. The bulboventricular sulcus will become visible from
29. By the time the heart tube has
30. The newly formed heart tube bulges into
31. The primitive heart tube can be subdivided
32. Early Development of the Heart
33. The partitioning of the atrium begins with
34. Before the septum primum fuses with the
35. Unlike the septum primum, septum secundum does
36. At the end of the 7th week
37. DEVELOPMENT OF THE HEART
38. Early Development of the Heart
39. Fate of the Sinus Venosus (Formation of
40. Conversely, the left vein counterparts are obliterated
41. Internally, the sinoatrial orifice is flanked by
42. Further into development the right sinus horn
43. The final morphological change in the heart
44. Truncal swellings: Right superior which grows distally
45. Pulmonary Veins (Formation of the Left Atrium)Development
46. The left atrium begins to expand gradually
47. Recall that the proximal bulbus cordis gives
48. At approximately day 42 the superior and
49. The final morphological change in the heart
50. In the newly formed bulboventricular loop the
51. During the shifting of the atrioventriclar canal
52. Secundum type involves septum primum or septum
53. In this case, the ostium primum is
54. Truncal swellings: Right superior which grows distally
55. Secundum Atrial Septal DefectThis type involves septum
56. Persistent Atrio-ventricular CanalThe persistent atrioventricular canal results
57. In the case of a VSD there
58. Transposition of the Great Vessels Transposition is a
59. Persistent Truncus Arteriosus A persistent truncus arteriosus results
60. Tetralogy of Fallotright ventricular hypertrophy due to
61. DextrocardiaDextrocardia is an anomaly in which the
62. The embryo is shaped in a modified
63. MAIN STAGES OF THE ERALY HEART DEVELOPMENT
64. Heart chambers are filled with plasma and
65. The embryo curves into a C shape.
66. Septum primum fuses with septum intermedium in the heart.Stage 19, (approximately 47-48 post ovulatory days)
67. Stage 14, 5th weekLens Pit and Optic
68. Blood flow through the arioventricular canal is
69. Stage 16 (6th weeks post fertilization) Primary
70. Stage 17(approximately 41 postovulatory days) A Four
71. Within the heart, the trunk of the
72. CONGENITAL MALFORMATIONS OF THE HEART AND GREAT
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74. Похожие презентации

THE OBJECTIVES:

Development of the HeartLecture for the general medicine IInd course english medium

EARLY DEVELOPMENT OF THE EMBRYO Middle of the 3rd week

DEVELOPMENT OF THE HEART PRIMODIUMAt first the angiogenic clusters are located on

DEVELOPMENT OF THE PRIMITIVE HEART B – transverse section shows the

DEVELOPMENT OF THE PRIMITIVE HEARTCephalocaudal section showing the position of the cardiogenic

DEVELOPMENT OF THE PRIMITIVE HEART 21-22 day – cephalocaudal folding,

DEVELOPMENT OF THE HEART23-24 day, as a result of brain growth

Cells of splanchnic mesodermal layer form the visceral layer of the serous

Stage 9 Appearance of Somites 1.5 - 2.5 mm19 - 21 days

The origins of the heart tube are clusters of angiogenic cells which

When the neural tube grows it pulls with it the prochordal plate

Angiogenic cell clusters which lie in a horse-shoe shape configuration in the

These angiogenic cell clusters coalesce to form right and left endocardial tubes.Each

The lateral and cranial folding of the embryo forces the tubes into

As the single heart tube is being formed the mesoderm around it

At approximately day 21 the endocardial tubes are completely fused. The heart

The single tubular heart develops many constrictions outlining future structures. The cranial

Early Development of the HeartThe newly formed heart tube may be divided

The original paired cardiac tubes fuse, with the

The bulboventricular portion of the heart grow faster than the pericardial sac

The bulboventricular sulcus will become visible from the outside, and from the

By the time the heart tube has formed the bulboventricular loop, the

The newly formed heart tube bulges into the pericardial cavity and is

The primitive heart tube can be subdivided into primordial heart chambers starting

The partitioning of the atrium begins with the appearance of septum primum

Before the septum primum fuses with the endocardial cushions, perforations appear in

Unlike the septum primum, septum secundum does not fuse with the endocardial

At the end of the 7th week the human heart has reached

Fate of the Sinus Venosus (Formation of the Right Atrium)Communication between the

Conversely, the left vein counterparts are obliterated and the left sinus horn

Internally, the sinoatrial orifice is flanked by two valves, the right and

Further into development the right sinus horn is incorporated into the expanding

The final morphological change in the heart is the partitioning of the

Truncal swellings: Right superior which grows distally and to the left. Left

Pulmonary Veins (Formation of the Left Atrium)Development of the left atrium occurs

The left atrium begins to expand gradually accepting the four branches. As

Recall that the proximal bulbus cordis gives rise to the right ventricle.

At approximately day 42 the superior and inferior cushions fuse forming a

In the newly formed bulboventricular loop the primitive right and left ventricles

During the shifting of the atrioventriclar canal the proximal bulbus cordis expands

Secundum type involves septum primum or septum secundum.Atrial Septal DefectIn a heart

In this case, the ostium primum is patent because the septum primum

Secundum Atrial Septal DefectThis type involves septum primum and/or septum secundum. In

Persistent Atrio-ventricular CanalThe persistent atrioventricular canal results from the failure of the

In the case of a VSD there is a massive left to

Transposition of the Great Vessels Transposition is a condition in which the aorta

Persistent Truncus Arteriosus A persistent truncus arteriosus results when the truncoconal swellings fail

Tetralogy of Fallotright ventricular hypertrophy due to the shunting of blood from

DextrocardiaDextrocardia is an anomaly in which the primitive heart tube folds to

The embryo is shaped in a modified S curve. The embryo has

MAIN STAGES OF THE ERALY HEART DEVELOPMENT

Heart chambers are filled with plasma and blood cells making the heart

The embryo curves into a C shape. The arches that form the

Septum primum fuses with septum intermedium in the heart.Stage 19, (approximately 47-48 post ovulatory days)

Stage 14, 5th weekLens Pit and Optic Cup Appear, Endolymphatic Appendage DistinctSemilunar

Blood flow through the arioventricular canal is divided into left and right

Stage 16 (6th weeks post fertilization) Primary cardiac tube separates into aortic

Stage 17(approximately 41 postovulatory days) A Four Chambered Heart and a Sense

Within the heart, the trunk of the pulmonary artery separates from the

CONGENITAL MALFORMATIONS OF THE HEART AND GREAT VESSELS.They are common.The overall incidence

Ventricular Septal Defects involve the membranous portion of the septum. The occur

Слайды презентации

Слайд 2 THE OBJECTIVES:

Слайд 3 GENERAL PROVISIONS:

Слайд 4 EARLY DEVELOPMENT OF THE EMBRYO
Middle

of the 3rd week – presomite stage, pan-cake appearance

of embryonic disc, intraembryonic endoderm constitutes the roof of the spherical yolk sac.
Formation of the angiogenic cell clusters: splanchnic mesoderm gives rise to angioblasts – cells of the mesenchymal origin condensing into interconnecting cords of cells.

Слайд 5 DEVELOPMENT OF THE MESODERM

Слайд 6 DEVELOPMENT OF THE MESODERM

Слайд 7 DEVELOPMENT OF THE HEART PRIMODIUM
At first the angiogenic

DEVELOPMENT OF THE HEART PRIMODIUMAt first the angiogenic clusters are located

clusters are located on the lateral sides of the

embryo, but they rapidly spread in a cephalic direction. The anterior central portion of these clusters is known as the cardiogenic area (region).

Слайд 8 DEVELOPMENT OF THE PRIMITIVE HEART
B –

transverse section shows the position of the angiogenic cell

clusters in the splanchnic mesoderm layer.
On day 19 a pair of vasсular elements called endocardial tubes begin to develop in the cardiogenic region, a horseshoe-shaped zone of splanchnopleuric mesoderm located cranial and lateral to the neural plate on the embryonic disc.

Слайд 9 DEVELOPMENT OF THE PRIMITIVE HEART
Cephalocaudal section showing the

DEVELOPMENT OF THE PRIMITIVE HEARTCephalocaudal section showing the position of the

position of the cardiogenic area and pericardial cavity (part

of the intraembryonic coelom) in the cranial end of the embryo.

Слайд 10 DEVELOPMENT
OF THE
PRIMITIVE HEART
21-22

DEVELOPMENT OF THE PRIMITIVE HEART 21-22 day – cephalocaudal folding, formation

day – cephalocaudal folding, formation of the fore-, hind-and

midgut. The heart primodium is pulled caudally.

Слайд 11 DEVELOPMENT OF THE HEART
23-24 day, as a

result of brain growth and cephalo-caudal folding the prechordal

plate (future bucco-pharyngeal membrane) is pulled forward, while primodium of the heart becomes located first in the cervical region,

End of the 1st month – and then in the thoracic region.

Слайд 12 Cells of splanchnic mesodermal layer form the visceral

Cells of splanchnic mesodermal layer form the visceral layer of the

layer of the serous membranes covering the abdominal organs,

lungs and heart. Visceral and parietal layers are continuous with each other as the dorsal mesentery, which suspends the gut tube in the peritoneal cavity. Ventral mesentery is a result of thinning of septum transversum.

DEVELOPMENT OF THE SEROUS MEMBRANES

Слайд 13
Stage 9
Appearance of Somites
1.5 - 2.5

Stage 9 Appearance of Somites 1.5 - 2.5 mm19 - 21

mm
19 - 21 days post-ovulation
By stage 9, if you

could look at the embryo from a top view, it would resemble the sole of a shoe with the head end wider than the tail end, and a slightly narrowed middle.
The first pair of somites appear at the tail and progress to the middle. One to three pairs of somites are present by Stage 9.

EARTY DEVELOPMENT
OF HEART

Vascular system appears in the middle of the 3rd week when the embryo is no longer able to satisfy its nutritional require-
ments by diffusion alone.

Слайд 14

Слайд 15 The origins of the heart tube are clusters

The origins of the heart tube are clusters of angiogenic cells

of angiogenic cells which are located in the cardiogenic

plate. The cardiogenic plate, which is derived from splanchnoplueric mesoderm, is located cranial and lateral to the neural plate.

Early Development of the Heart

Superior view of embryo
at 16/17

Слайд 16 When the neural tube grows it pulls with

When the neural tube grows it pulls with it the prochordal

it the prochordal plate (Oropharyngeal membrane) and the central

part of the cardiogenic plate forward causing the central portion of the cardiogenic plate and pericardial portion of the intraembryonic coelomic cavity to move from it's original rostral position to the buccopharyngeal membrane to a ventral and caudal position.

Early
Development
of the Heart

Слайд 17 Angiogenic cell clusters which lie in a horse-shoe

Angiogenic cell clusters which lie in a horse-shoe shape configuration in

shape configuration in the plate coalesce to form two

endocardial tubes. These tubes are then forced into the thoracic region due to cephalic and lateral foldings where they fuse together forming a single endocardial tube.

EARLY DEVELOPMENT OF THE HEART

Слайд 18 These angiogenic cell clusters coalesce to form right

These angiogenic cell clusters coalesce to form right and left endocardial

and left endocardial tubes.
Each tube is continuous cranially with

a dorsal aorta, its outflow tract, and caudally with a vitelloumbilical vein, its inflow tract.

Early Development
of the Heart

Day 20

Слайд 19 The lateral and cranial folding of the embryo

The lateral and cranial folding of the embryo forces the tubes

forces the tubes into the thoracic cavity. As a

result, these tubes come to lie closer to each other and begin to fuse in a cranial to caudal direction.

Early Development of the Heart

Слайд 20 As the single heart tube is being formed

As the single heart tube is being formed the mesoderm around

the mesoderm around it thickens to form the myoepicardial

mantle, this is at first separated from the endothelial tube by the cardiac jelly, which later is invaded by mesenchymal cells. The endothelial layer forms the endocardium and the myoepicardial mantle gives rise to the myocardium and the visceral pericardium (epicardium).

Formation
of the Myocardium and Epicardium

Слайд 21 At approximately day 21 the endocardial tubes are

At approximately day 21 the endocardial tubes are completely fused. The

completely fused.
The heart starts to beat at day

22, but the circulation does not start until days 27 to 29.

Early Heart Development, SEM

Слайд 22

Слайд 23 The single tubular heart develops many constrictions outlining

The single tubular heart develops many constrictions outlining future structures. The

future structures. The cranial most area is the bulbus

cordis which extends cranially into the truncus arteriosus, which in turn is connected to the aortic sac and through the aortic arches to the dorsal aorta. The primitive ventricle is caudal to the bulbus cordis and the primitive atrium is the caudal most structure of the tubular heart. The atrium which is paired connects to the sinus venosus which receives the viteline (from yolk sac), common cardinal (from embryo) and umbilical (from primitive placenta) veins. The primitive atrium and sinus venosus lay outside the caudal end of the pericardial sac, and the truncus arteriosus is outside the cranial end of the pericardial sac.

Слайд 24 Early Development of the Heart
The newly formed heart

Early Development of the HeartThe newly formed heart tube may be

tube may be divided into regions. Starting caudally:
sinus

venosus - consisting of right and left horns,

paired primitive atria. These structures will later fuse together to form common atrium,

atrioventricular sulcus divides the atria and the primitive ventricle.

primitive ventricle expands to become the left ventricle.

interventricular sulcus divides the primitive ventricle and the bulbus cordis,

bulbus cordis which may be divided as follows:

conus cordis

truncus arteriosus aortic sac.

bulbus cordis - the proximal portion forms the right ventricle

Слайд 25 Early Heart Development

Слайд 26 The original paired cardiac tubes fuse, with the

"ventricular" primordia initially lying above the "atria".
Growth of

the cardiac tube flexes it into an "S-shape" tube, rotating the "ventricles“.

Early Development of the Heart

Слайд 27 The bulboventricular portion of the heart grow faster

The bulboventricular portion of the heart grow faster than the pericardial

than the pericardial sac and the rest of the

embryo. Since the bulboventricular portion is fixed at the cranial end by the aortic arch arteries and at it's caudal end by the septum transversum, the bulboiventricular portion will fold as it elongates.
The cephalic end of the heart tube will bend ventrally, caudally and slightly to the right.

Early Development of the Heart

Слайд 28 The bulboventricular sulcus will become visible from the

The bulboventricular sulcus will become visible from the outside, and from

outside, and from the inside there will be a

primitive interventricular foramen. The internal fold formed by the bulboventricular sulcus is known as the bulboventricular fold. The bulboventricular segment of the heart is now U-shaped, bulbus cordis occupies the right arm of the U-shape and the primitive ventricle occupy the left arm of the U-shaped bulbo-ventricular segment. The looping of the bulboventricular segment of the heart will cause the atrium and sinus venosus to become dorsal to the heart loop.

LOOPENING

Слайд 29 By the time the heart tube has formed

By the time the heart tube has formed the bulboventricular loop,

the bulboventricular loop, the two primitive right and left

atria have fused to form a common atrium. Note that it now lies cranial to the primitive ventricle and dorsal to the bulbus cordis. The truncus arteriosus lies on the roof of the common atrium causing a depression and indicates where septation of the atrium will occur. AS = Aortic sac, BC = Bulbus cordis, CC = Conus cordis, LA = Left atrium, LV = Left ventricle, RA = Right atrium
SV = Sinus venosus, TA = Truncus arteriosus.

LOOPENING

Слайд 30 The newly formed heart tube bulges into the

The newly formed heart tube bulges into the pericardial cavity and

pericardial cavity and is attached to the dorsal wall

by a fold of tissue, the dorsal mesoderm. This is a derivative of foregut splanchnoplueric mesoderm. Eventually this will rupture leaving the heart tube suspended in the pericardial cavity anchored cranially by the dorsal aortae and caudally by the vitelloumbilical veins.
As it bulges into the cavity it becomes invested in a layer of myocardium. A layer of acellular matrix, the cardiac jelly, separates the myocardium and the endothelial heart tube.

Слайд 31 The primitive heart tube can be subdivided into

The primitive heart tube can be subdivided into primordial heart chambers

primordial heart chambers starting caudally at the inflow end:

the sinus venosus, primitive atria, ventricle, and bulbus cordis (conus).

Слайд 32 Early Development of the Heart

Слайд 33 The partitioning of the atrium begins with the

The partitioning of the atrium begins with the appearance of septum

appearance of septum primum at about the 28th day.

This is a crest of tissue that grows from the dorsal wall of the atrium towards the endocardial cushions - the ostium (opening) formed by the free edge of septum primum is the ostium primum.

ATRIAL PARTITIONING

Слайд 34 Before the septum primum fuses with the endocardial

Before the septum primum fuses with the endocardial cushions, perforations appear

cushions, perforations appear in the upper portion of the

septum primum. These perforations will coalesce to form the ostium secundum.
SAO = Sinoatrial orifice
SS = Septum spurium
S1 = Septum primum
Perf = Perforations
O1 = Ostium secundum
EC = Endocardial cushions

ATRIAL PARTITIONING

Слайд 35 Unlike the septum primum, septum secundum does not

Unlike the septum primum, septum secundum does not fuse with the

fuse with the endocardial cushions. Its free edge forms

the foramen ovale. The left venous valve and the septum spurium located on the dorsal wall of the right atrium, fuse with the septum secundum as it grows.
EC = Endocardial cushions, LVV = Left venous valve, O1 = Ostium secundum, SS = Septum spurium, S1 = Septum primum, S2 = Septum secundum.

ATRIAL PARTITIONING

Слайд 36 At the end of the 7th week the

At the end of the 7th week the human heart has

human heart has reached its final stage of development.

Because the fetus does not use its lungs, most of the blood is diverted to the systemic circulation. This is accomplished by a right to left shunting of blood that occurs between the two atria.
The foramen ovale and the septum primum control this right and left communication. The septum primum acts as a valve over the foramen ovale. At birth the child will use its lungs for the first time and consequently more blood will flow into the pulmonary circulation. The pressure increase in the left atrium (where the pulmonary veins empty) will force septum primum to be pushed up against septum secundum. Shortly thereafter the two septa fuse to form a common atrial septum.

FO - foramen ovale

ATRIAL PARTITIONING

Слайд 37 DEVELOPMENT OF THE HEART

Слайд 38 Early Development of the Heart

Слайд 39 Fate of the Sinus Venosus (Formation of the

Fate of the Sinus Venosus (Formation of the Right Atrium)Communication between

Right Atrium)
Communication between the sinus venosus and the primitive

atrium, the sinoatrial orifice, is centrally located.

VV = Vitelline vein
UV = Umbilical vein
CC = Common cardinal vein
SA = Sinoatrial orifice
RSH, LSH = right, left sinus
horn
RA, LA = right, left atrium

Unlike the atria, the sinus vinosus remains a paired structure with right and left horns. Each horn receives venous blood from three vessels:

Vitelline vein

Umbilical vein

Commom cardinal vein

Слайд 40 Conversely, the left vein counterparts are obliterated and

Conversely, the left vein counterparts are obliterated and the left sinus

the left sinus horn diminishes in size and forms

the coronary sinus and the oblique vein of the left ventricle.

SVC = Superior vena cava
IVC = Inferior vena cava
SA = Sinoatrial junction
CS/OV = Coronary sinus/ oblique
vein of left ventricle
LA, RA = Left, right atrium
LV, RV = Left, right ventricle

DEVELOPMENT
OF THE ATRIA

Gradually the sinoatrial oriface shifts to the right, due to the shunting of blood to the right, until the sinus venosus communicates with only the right atrium. The fate of each structure is as follows:

the right sinus horn becomes enlarged

the right anterior cardinal vein becomes the superior vena cava

the right vitelline vein becomes the inferior vena cava

the right umbilical vein is obliterated

Слайд 41 Internally, the sinoatrial orifice is flanked by two

Internally, the sinoatrial orifice is flanked by two valves, the right

valves, the right and left venous valves. Superiorly these

two valves meet to form the septum spurium. Note that the left horn opens up underneath the orifice of the right horn (sinoatrial oriface). This is the orifice of the coronary sinus.

LVV, RVV = left, right venous
valve
SS = Septum spurium
SA = Sinoatrial oriface
OCS = orifice of the coronary
sinus

SEPTATION

Слайд 42 Further into development the right sinus horn is

Further into development the right sinus horn is incorporated into the

incorporated into the expanding right atium. As the atrium

expands the smooth tissue of the sinus venosus displaces the trabeculated tissue of the primitive right atrium anteriorly and laterally where it becomes the adult right auricle. The smooth tissue forms part of the atrium called the sinus venarum. Crista Terminalis, a ridge of tissue located to the right of the sinoatrial orifice, forms the boundary between the auricle and the sinus venarum.

RAu = Right auricle
SV = Sinus venarum
CT = Crista terminalis
OCS = Orifice of the
coronary sinus

Formation of the Right Auricle

Слайд 43 The final morphological change in the heart is

The final morphological change in the heart is the partitioning of

the partitioning of the outflow tract - - the

truncus arteriosus and the conus cordis - - into the aorta and the pulmonary trunk. This is accomplished by the development of a septum that forms in the outflow tract and the emergence of the two great vessels.
The septum forms from two pairs of swellings which grow from the walls of the outflow tract. These are the truncus swellings and the conus swellings.

Formation of the Aorta and
Pulmonary Tract

RSTS/ LITS = Right superior/
Left inferior truncal swelling,

RDCS/ LVCS = Right dorsal/
Left ventral conus swelling

Слайд 44 Truncal swellings: Right superior which grows distally and

Truncal swellings: Right superior which grows distally and to the left.

to the left. Left inferior which grows distally and

to the right. Both develop at the proximal part of the truncus and proceed to grow in two directions; 1) distally towards the aortic sac and 2) into the lumen of the outflow tract where they will eventually fuse together.
Conus swellings: Right dorsal which is continuous with the right superior Left ventral which is continuous with the left inferior Like the truncal swellings, the conal swellings grow distally and towards each other, however they appear after the first pair. These conus swellings eventually fuse with the truncal swellings.

Formation of the Aorta and
Pulmonary Tract

RSTS/ LITS = Right superior/
Left inferior truncal swelling,

RDCS/ LVCS = Right dorsal/
Left ventral conus swelling

Слайд 45 Pulmonary Veins (Formation of the Left Atrium)
Development of

Pulmonary Veins (Formation of the Left Atrium)Development of the left atrium

the left atrium occurs concurrently with that of the

right atrium. During the early part of the fourth week an outgrowth of the pulmonary veins appear from the left atrium. This "sprout" will bifurcate until there are four veins. These vessels will then grow towards the lung buds.

LA = Left atrium

OPV = orifice of
pulmonary vein

PV = pulmonary vein

Слайд 46 The left atrium begins to expand gradually accepting

The left atrium begins to expand gradually accepting the four branches.

the four branches. As the atrial wall expands, the

smooth tissue of the pulmonary veins is incorporated into the wall of the atrium and displaces the trabeculated tissue anteriorly and laterally which will then form the adult auricles. Compare this process to the formation of the adult right auricle.

LAu = Left auricle

OPV = Orifice of
the four pulmo-
nary veins

PV = four pulmo-
nary veins

Pulmonary Veins (Formation of the Left Atrium)

Слайд 47 Recall that the proximal bulbus cordis gives rise

Recall that the proximal bulbus cordis gives rise to the right

to the right ventricle. Thus, blood flows from the

primitive atrium to the left ventricle then to the right ventricle. There is no direct communication between the atria and the right ventricle even after the formation of the bulboventriclular loop. The atrioventricular canal must shift to the right in order to acheive communication to the right ventricle in addition to the left ventricle. During this shift the proximal bulbus widens and the bulboventricular flange begins to recede. Swellings of mesenchymal tissue, the endocardial cushions, appear on the borders of the atrioventricular canal. There are four cushions: inferior and superior (ventral and dorsal), left and right. The first appear before the latter. These swellings give the atrioventricular canal a "dog's bone" shape.

AVC = Atrioventricular
canal

BC = Bulbus Cordis

LV = Left ventricle

Atrioventricular
Canals

Слайд 48 At approximately day 42 the superior and inferior

At approximately day 42 the superior and inferior cushions fuse forming

cushions fuse forming a right and a left atrioventricular

canal. The left atrium communicates with the left ventricle and the right atrium communicates with the right ventricle. The shifting process brings the conus cordis to lie superior to the interventricular foramen, which at this point, has not yet been obliterated. The fused endocardial cushions are also responsible for the closure of the ostium primum by fusing with the free edge of the septum primum.

R/LAVC = Right/left
atrioventricular canal

Atrioventricular Canals

Слайд 49 The final morphological change in the heart is

the partitioning of the outflow tract - - the

Formation of the Aorta and
Pulmonary Tract

RSTS/ LITS = Right superior/
Left inferior truncal swelling,

RDCS/ LVCS = Right dorsal/
Left ventral conus swelling

Слайд 50 In the newly formed bulboventricular loop the primitive

In the newly formed bulboventricular loop the primitive right and left

right and left ventricles appear as expansions in the

heart tube. Externally the interventricular sulcus separates the right and left ventricles and internally they are separated by the bulboventricular flange. Remember that the right ventricle arises from the proximal bulbus cordis.

AVC = Atrioventricular
canal

BC = Bulbus Cordis

BVF = Bulboventricular
flange

IVS = Interventricular
sulcus

RV = Right ventricle

LV = Left ventricle

Formation of the Ventricles

Слайд 51 During the shifting of the atrioventriclar canal the

During the shifting of the atrioventriclar canal the proximal bulbus cordis

proximal bulbus cordis expands forming the right ventricle. Both

ventricles will continue to expand until the late 7th/early 8th week. The growth of the ventricles is due to the centrifugal growth of the myocardium and the diverticulation of the internal walls. (This is what gives the ventricle its trabeculated appearance). The muscular interventricular septum forms as a result of the expanding ventricles. The walls of the right and left ventricles grow in opposition to each other to form the muscluar septum. Thus, the septum will cease to grow when the ventriclar walls are no longer expanding.

BC = Bulbus cordis

IVS = Interventricular
septum

MC = Myocardium

RV = Right ventricle

Formation of the Ventricles

Слайд 52 Secundum type involves septum primum or septum secundum.
Atrial

Secundum type involves septum primum or septum secundum.Atrial Septal DefectIn a

Septal Defect
In a heart with an Atrial Septal Defect

(ASD) there is communication between the right and left atria which causes a left to right shunting of blood due to the lower pressure in the pulmonary circulatory system. Consequently there is a mixing of oxygenated (systemic) and deoxygenated (pulmonary) blood.

There are two types of ASD:

Primum type involves the endocardial cushions.

Слайд 53 In this case, the ostium primum is patent

In this case, the ostium primum is patent because the septum

because the septum primum does not fuse with the

endocardial cushions. Recall that the cushions are responsible in forming a portion of septum primum, thus obliterating ostium primum.

FO = Foramen ovale

IEC = Inferior endocardial
cushion

SEC = Superior endocar-
dial cushion

O1 = ostium primum

Primum Type ASD

Слайд 54 Truncal swellings: Right superior which grows distally and

to the left. Left inferior which grows distally and

Formation of the Aorta and
Pulmonary Tract

RSTS/ LITS = Right superior/
Left inferior truncal swelling,

RDCS/ LVCS = Right dorsal/
Left ventral conus swelling

Слайд 55 Secundum Atrial Septal Defect
This type involves septum primum

Secundum Atrial Septal DefectThis type involves septum primum and/or septum secundum.

and/or septum secundum. In both cases the result is

a patent foramen ovale.
There may be excessive resorbtion of septum primum where very little septum remains or it has been completely resorbed. The short septum primum does not overlap the foramen ovale leaving a communication between right and left atrium. If the septum secundum is involved it is because it did not reach its full growth and thus results in a large foramen ovale.

FO = Foramen
ovale

S1 = Septum
primum

S2 = Septum
secundum

Слайд 56 Persistent Atrio-
ventricular Canal
The persistent atrioventricular canal results from

Persistent Atrio-ventricular CanalThe persistent atrioventricular canal results from the failure of

the failure of the superior and inferior cushions to

fuse. Thus there is a single atrioventricular canal in which all four chambers may freely communicate. Because the cushions do not fuse the atrial and ventricular septa cannot fully form as they rely on the cushions to form the membranous portions of these septa.

IEC = Inferior endocardial
cushion

SEC = Superior endocardial
cushion

PAVC = Persistent
atrioventricular canal

S1 = Septum primum

S2 = Septum secundum

Слайд 57 In the case of a VSD there is

In the case of a VSD there is a massive left

a massive left to right shunting of blood and

pulmonary hypertension. The absence of the interventricular septum results in a Common Ventricle.

Ventricular
Septal Defect

Mem = Membra-
nous septum

Musc = Muscu-
lar septum

The ventricular septal defect is the most common of all congenital heart anomalies. It may be caused by any of the four malformations:

Deficient development of the proximal conus swellings.

Failure of the muscular portion of the interventricular septum to fuse with the free edge of the conus septum. (Membranous VSD)

Failure of the endocardial cushions to fuse.

Excessive diverticulation of the muscular septum- perforations in the muscular interventricular septum. (Muscular VSD)

Слайд 58 Transposition of the Great Vessels
Transposition is a condition

Transposition of the Great Vessels Transposition is a condition in which the

in which the aorta arises from the right ventricle

and the pulmonary trunk from the left. This anomally is due to the failure of the truncoconal swellings to grow in the normal spiral direction. There is also a ventricular septal defect and a patent ductus arteriosus. However, these secondary defects make life possible as they provide a way for oxygenated blood to reach the entire body.

AO = Aorta

PT = Pulmonary
trunk

PDA = Persistent
Dunctus Arteriosus

RV/LV = right and
left ventricles

Слайд 59 Persistent Truncus Arteriosus
A persistent truncus arteriosus results when

Persistent Truncus Arteriosus A persistent truncus arteriosus results when the truncoconal swellings

the truncoconal swellings fail to grow. The single artery,

the truncus arteriosus, arises from both ventricles above the ventricular septal defect, allowing pulmonary and systemic blood to mix. Distally, the single artery is divided into the aorta and pulmonary trunk by an incomplete septum.

AO = Aorta

PT = Pulmonary
trunk

PTA = Persistent
truncus arterio-
sus

RV/LV = Right
and left ventricles

Слайд 60 Tetralogy of Fallot
right ventricular hypertrophy due to the

Tetralogy of Fallotright ventricular hypertrophy due to the shunting of blood

shunting of blood from left to right. (The pressure

in the right ventricle is increased causing the walls of the right ventricle to expand.)

AO = Aorta

PT = Pulmonary trunk
(stenotic)

RV/LV = Right and left
ventricles

This condition results from a single error: the conus septum develops too far anteriorly giving rise to two unequally proportioned vessels- - a large aorta and a smaller stenotic pulmonary trunk. The four main characteristics of Tetralogy of Fallot are:

pulmonary stenosis

ventricular septal defect (VSD) of the membranous portion (the septum is displaced too far anteriorly to contribute to the septum)

overriding aorta (the aorta straddles the VSD)

Слайд 61 Dextrocardia
Dextrocardia is an anomaly in which the primitive

DextrocardiaDextrocardia is an anomaly in which the primitive heart tube folds

heart tube folds to the left in a mirror

image of a normal bulboventricular loop. This usually occurs when all the organ systems are reversed, a condition called situs inversus.

RA/LA = Right and left atrium

RV = Right ventricle

BC = Bulbus cordis

Слайд 62
The embryo is shaped in a modified S

The embryo is shaped in a modified S curve. The embryo

curve. The embryo has a bulb-like tail and a

connecting stalk to the developing placenta.
A primitive S-shaped tubal heart is beating and peristalsis, the rhythmic flow propelling fluids throughout the body, begins. However, this is not true circulation because blood vessel development is still incomplete.

Stage 11

13-20 Somite Pairs, Rostral
Neuropore Closes, Optic Vesicle

Appears,

Two Pharyngeal Arches Appear
2.5 - 3.0 mm
23 - 25 days post-ovulation

Time-Line Schedule of Heart Development

Слайд 63 MAIN STAGES OF THE ERALY
HEART DEVELOPMENT

Слайд 64
Heart chambers are filled with plasma and blood

Heart chambers are filled with plasma and blood cells making the

cells making the heart seem distended and prominent. The

heart and liver combined are equal in volume to the head by this stage. Blood circulation is well established, though true valves are not yet present.

Stage 13 (approximately 27-29 postovulatory days)
Four Limb Buds, Lens Disc and Optic Vesicle, the first thin surface layer of skin appears covering the embryo. 30-40 somite pairs.

Слайд 65
The embryo curves into a C shape. The

The embryo curves into a C shape. The arches that form

arches that form the face and neck are now

becoming evident under the enlarging forebrain. A blood system continues to develop. Blood cells follow the surface of yolk sac where they originate, move along the central nervous system, and move in the chorionic villi, the maternal blood system. Valves and septa may appear in the heart in Stage 12.

Stage 12
21-29 Somite Pairs, Caudal Neuropore Closes, Three to Four Pharyngeal Arches Appear, Upper Limb Buds Appear
3.0 - 5.0 mm
25 - 27 days post-ovulation

Слайд 66
Septum primum fuses with septum intermedium in the

heart.
Stage 19,
(approximately
47-48 post ovulatory days)

Слайд 67
Stage 14, 5th week
Lens Pit and Optic Cup

Stage 14, 5th weekLens Pit and Optic Cup Appear, Endolymphatic Appendage

Appear, Endolymphatic Appendage Distinct
Semilunar valves begin to form in

the heart. Four major subdivisions of the heart (the trabeculated left and right ventricles, the conus cords and the truncus arteriosus) are clearly defined. Two sprouts, a ventral one from the aortic sac and a dorsal one from the aorta, form the pulmonary (sixth aortic) arch.

Слайд 68

Blood flow through the arioventricular canal is divided

Blood flow through the arioventricular canal is divided into left and

into left and right streams, which continue through the

outflow tract and aortic sac. The left ventricle is larger than the right and has a thicker wall.

Stage 15
(6 to 8 weeks post fertilization)
Lens Vesicle, Nasal Pit, Hand Plate; Trunk Widens, Future Cerebral Hemispheres Distinct

Слайд 69
Stage 16
(6th weeks post fertilization)
Primary cardiac

Stage 16 (6th weeks post fertilization) Primary cardiac tube separates into

tube separates into aortic and pulmonary channels and the

ventricular pouches deepen and enlarge, forming a common wall with their myocardial shells.

Слайд 70
Stage 17
(approximately 41 postovulatory days)
A Four Chambered

Stage 17(approximately 41 postovulatory days) A Four Chambered Heart and a

Heart and a Sense of Smell
The heart begins to

separate into four chambers.

Слайд 71
Within the heart, the trunk of the pulmonary

Within the heart, the trunk of the pulmonary artery separates from

artery separates from the trunk of the aorta.
Stage

18, 44 days
Ossification of the Skeleton Begins

Слайд 72 CONGENITAL MALFORMATIONS OF THE HEART AND GREAT VESSELS.
They

CONGENITAL MALFORMATIONS OF THE HEART AND GREAT VESSELS.They are common.The overall

are common.
The overall incidence is 0.7% of live births

and 2.7% of stillbirths.
Atrial Septal Defects (ASD) – are among the most common (6.4/10,000births).
One of the most significant defects is ostium secundum defect. This anomaly is characterized by a large opening between the left and the right atria and is caused either by excessive cell death or resoption of the septum primum. Or by inadequate development of the septum secundum. Depending on the size of the opening considerable intercardiac shunting may occur from left to the right.