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Презентация на тему Acute and chronic glomerulonephritis

Glomerulonephritis (GN), also known as glomerular nephritis, is a term used to refer to several kidney diseases (usually affecting both kidneys). Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the
JSC “Astana Medical University” Department of Internal Diseases №1 SIWTheme: acute and Glomerulonephritis (GN), also known as glomerular nephritis, is a term used EtiologyInfectious- Streptococcal -Nonstreptococcal postinfectious glomerulonephritis    Bacterial Pathogenesis of GlomerulonephritisCausative agent activates in organism an immunopathological processFormation of immune SclerotherapyProliferation and activation of mesangial cellsChanges in the physico-chemical properties of the ClassificationGlomerulonephritisAcute (10%)Chronic (70%) Subacute (1%) Acute glomerulonephritisIt is an acute immunoinflammatory disease of the kidneys with the SyndromsNephrotic syndrome Hypertonic syndromeMixed syndrome Acute glomerulonephritis Diagnostics of AGFull blood countClinical urine analysisDetermination of creatinine, urea, uric acid Treatment of AGDiet №7Antibiotics:   - Benzylpenicillin 1 000 000-2 000 Antiaggregants - dipyridamole tablets of 25 mg, film-coated, 75 mg/day, tab; pentoxifylline 100 mg/day amp. With antihypertensive and nephroprotectivepurpose, angiotensin-converting enzymeinhibitors:- fozinopril 20 mg/day, - enalapril 20 Chronic glomerulonephritisIt is the same as an acute form. It can bedifficult Diagnostics of CG1. General blood test: HB, Erythrocytes, Leukocytes, Platelets, ESR before Treatment of CGGlucocorticoids:   - Prednisolone 1 mg/kg 2 months endovenousCytostatics: Antiaggregants and anticoagulants:   - Dipyridamole 400-600 mg/day   - Clopidogrel 0,2-0,3 g/day Antihypertensive therapy:    ACE inhibitor    - Captopril References «Glomerulonephritis
Слайды презентации

Слайд 2 Glomerulonephritis (GN), also known as glomerular nephritis,

Glomerulonephritis (GN), also known as glomerular nephritis, is a term used

is a term used to refer to several kidney diseases (usually

affecting both kidneys). Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the kidneys, but not all diseases necessarily have an inflammatory component.

Слайд 3 Etiology
Infectious
- Streptococcal
-Nonstreptococcal postinfectious glomerulonephritis

EtiologyInfectious- Streptococcal -Nonstreptococcal postinfectious glomerulonephritis  Bacterial  Viral  ParasiticNoninfectious StreptococcalMultisystem systemic diseasesPrimary glomerular diseases

Bacterial
Viral
Parasitic
Noninfectious

Streptococcal
Multisystem systemic diseases
Primary glomerular diseases

Слайд 4 Pathogenesis of Glomerulonephritis
Causative agent activates in organism an

Pathogenesis of GlomerulonephritisCausative agent activates in organism an immunopathological processFormation of

immunopathological process
Formation of immune complexes
In the blood: increase of

immune complexes and degrease of the СЗ-complement

Antigen of a streptococcus is an endostreptosin






Слайд 5 Sclerotherapy
Proliferation and activation of mesangial cells
Changes in the

SclerotherapyProliferation and activation of mesangial cellsChanges in the physico-chemical properties of

physico-chemical properties of the basal membrane, mesangium, endothelium, glomerular

epithelium and activation of platelet count



Changes in hemodynamics, hyperlipidemia


Слайд 6 Classification
Glomerulonephritis
Acute (10%)
Chronic (70%)
Subacute (1%)

ClassificationGlomerulonephritisAcute (10%)Chronic (70%) Subacute (1%)

Слайд 7 Acute glomerulonephritis
It is an acute immunoinflammatory disease of

Acute glomerulonephritisIt is an acute immunoinflammatory disease of the kidneys with

the kidneys with the initial lesion of the glomeruli

and involvement in the pathological process of all renal structures, clinically manifested by renal and adrenal symptoms

Слайд 9 Syndroms
Nephrotic syndrome
Hypertonic syndrome
Mixed syndrome

SyndromsNephrotic syndrome Hypertonic syndromeMixed syndrome

Слайд 12 Acute glomerulonephritis

Acute glomerulonephritis

Слайд 13 Diagnostics of AG
Full blood count
Clinical urine analysis
Determination of

Diagnostics of AGFull blood countClinical urine analysisDetermination of creatinine, urea, uric

creatinine, urea, uric acid
Calculation of the glomerular filtration

rate
Determination of total protein count, protein fractions
Determination of ALT, AST, cholesterol, bilirubin, total lipids
Determination of potassium, sodium, chlorides, iron, calcium, magnesium, phosphorus

Слайд 14 Treatment of AG
Diet №7
Antibiotics:
- Benzylpenicillin

Treatment of AGDiet №7Antibiotics:  - Benzylpenicillin 1 000 000-2 000

1 000 000-2 000 000 UA/day, 7-10 days.
Glucocorticoids:

- Prednisolone 50-60 mg/day 1-1,5 months

Слайд 15 Antiaggregants - dipyridamole tablets of 25 mg, film-coated,

Antiaggregants - dipyridamole tablets of 25 mg, film-coated, 75 mg/day, tab; pentoxifylline 100 mg/day amp.

75 mg/day, tab; pentoxifylline 100 mg/day amp.


Слайд 16 With antihypertensive and nephroprotective
purpose, angiotensin-converting enzyme
inhibitors:
- fozinopril 20

With antihypertensive and nephroprotectivepurpose, angiotensin-converting enzymeinhibitors:- fozinopril 20 mg/day, - enalapril

mg/day,
- enalapril 20 mg/day,
- ramipril 10 mg/day,

tab;

Слайд 17 Chronic glomerulonephritis
It is the same as an acute

Chronic glomerulonephritisIt is the same as an acute form. It can

form. It can be
difficult to detect it because of

the absence of
obvious symptoms (latent leakage), in contrast
to acute. The patient can feel quite normal, not
have puffiness, his urine is without blood.
Increased protein in the blood,
an increase in the number of
red blood cells can mean the
presence of the disease. If it
is not treated for a long time,
nephratonia develops.

Слайд 18 Diagnostics of CG
1. General blood test: HB, Erythrocytes,

Diagnostics of CG1. General blood test: HB, Erythrocytes, Leukocytes, Platelets, ESR

Leukocytes, Platelets, ESR before and after kidney biopsy
2. Test

strips for hematuria, proteinuria, leukocyturia
3. Protein / creatinine ratio
4. Creatinine, blood serum urea
5. Determination of clotting time
6. A biopsy of a kidney under the control of US
7. The account of the accepted and allocated liquid, daily measurement of weight
8. Determination of the concentration of Cyclosporine, Tacrolimus in serum

Слайд 19 Treatment of CG
Glucocorticoids:
- Prednisolone 1

Treatment of CGGlucocorticoids:  - Prednisolone 1 mg/kg 2 months endovenousCytostatics:

mg/kg 2 months endovenous
Cytostatics:
- Cyclophosphamide 2-3

mg/kg/day
- Chlorambucil 0,1-0,2 mg/kg/day
- Ciclosporin 2,5-3,5 mg/kg/day

Слайд 20 Antiaggregants and anticoagulants:
- Dipyridamole 400-600

Antiaggregants and anticoagulants:  - Dipyridamole 400-600 mg/day  - Clopidogrel 0,2-0,3 g/day

mg/day
- Clopidogrel 0,2-0,3 g/day


Слайд 21 Antihypertensive therapy:
ACE inhibitor

Antihypertensive therapy:  ACE inhibitor  - Captopril 50-100 mg/day

- Captopril 50-100 mg/day
-

Enalapril 10-20 mg/day
Сalcium channel blockers
- Nifedipine 20-40 mg/day
Antioxidants:
- Tocopherol



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