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Презентация на тему Therapyю Mental illness

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TREATMENT OF MENTAL DISORDERSBiological therapyPsychotherapySocial rehabilitation Methods of therapeutic effects on biological processes System of psychological methods of therapeutic effects on the psyche- a set of measures,aimed atmaximumadaptationthe mentally ill into society andtheir restorationprofessionalfunctioning. OPTIONS
Zaporozhe State University MEDITSINSYDepartment of Psychiatry, psychotherapy, general and medical psychology,narcology and sexologyTHERAPY  Mental illness TREATMENT OF MENTAL DISORDERSBiological therapyPsychotherapySocial rehabilitation Methods of therapeutic effects on biological HISTORY OF THERAPY  TrepanationJan van Hemessen (Jan Sanders van Hemessen)? HISTORY OF THERAPY  Straitjackets HISTORY OF THERAPY  'Shock' methodsElectro-convulsive therapy (ECT)The main indications:  resistant depression  HISTORY OF THERAPY Neurosurgical treatmentLOBOTOMYINDICATIONS:resistant depression,anxiety disorders,aggressive behavior in patients with schizophrenia. DRUG THERAPY OF MENTAL DISORDERSPsychotropic drugs are capable of regulating disturbed mental PSYCHOTROPIC DRUGS:  CLASSIFICATIONANTIPSYCHOTICS (NEUROLEPTICS)ANTIDEPRESSANTSANTIPARKINSONIANMOOD STABILIZERSPSYCH STIMULANTSNOOTROPICSANTIEPILEPTICANTIPARKINSONIANHYPNOTICS ANTIPSYCHOTICSThe main action - an antipsychotic (reduction of delusions and hallucinations?)The first HISTORY  antipsychoticsChlorpromazineRisperidoneHaloperidolClozapineOlanzapineQuetiapine196019701980199020001950FluphenazineThioridazineJibson MD, Tandon R. J Psychiatr Res 1998;32:215–228;Lehmann HE, Ban CLASSIFICATION  Antipsychotic- Have fewer extrapyramidal disordersEffectiveness at the negative symptoms of Do not induce extrapyramidal disorderssedation  the impact on the cardiovascular system  no PROLONGED FORMS OF ANTIPSYCHOTICSSpecific dosage forms neuroleptics, which, after the / m SIDE EFFECTS TYPICAL ANTIPSYCHOTICSD2Blockade of dopamine retseptrov:antipsychotic effect.hyperprolactinemianegative symptomstarditivnaya dyskinesiaAlpha1-adrenergic receptors - SIDE EFFECTS ATYPICAL ANTIPSYCHOTICS5НТ2А D2AtypicalantipsychoticsSerotonin 5HT2Aretseptory- blockade:regulation of releasedopamineDopamine D2 receptors -blokantipsychotic effecthyperprolactinemianegative symptomstardive dyskinesia SYMPTOMS:muscle rigiditytemperature risetrophic changesstupor. MALIGNANTneuroleptic syndromeTREATMENT:hospitalization in an intensive care unitcancellation of The surgery - consisting of mixtures for artificial hypothermia (chlorpromazine).In anesthesiology and ANTIDEPRESSANTSANTIDEPRESSANTeffects caused by antidepressantsPSYCHOGOGICSEDATIVETIMANALEPTICVEGETATIVE STABILIZINGANTIFOBICHYPNOTICHOLINOLITICANXIOLYTIC CLASSIFICATION ANTIDEPRESSANTS DEPENDING ON THE CLINICAL EFFECTAmitriptylineSTIMULATING EFFECTANXIOLYTIC EFFECTSEDATIVESEFFECTMIASERCitalopram (Cipramil)Sertraline (Zoloft)Paroxetine (Paxil)Milnacipran STH EFFECTS TRICYCLIC ANTIDEPRESSANTSRespiratorysystemCardiovascularsystemEndocrine systemUrinarysystemDigestivesystemDry mouthConstipation. Hepatotoxic actionurinary retentionSexual dysfunctionOrthostatic hypotensionproaritmogennoe effectasequenceReduced secretion of bronchial glands STH EFFECTS SELECTIVE SEROTONIN REUPTAKE INHIBITOREndocrine systemDigestivesystemWeight lossReduced secretion of salivary glandsDiarrheaNauseaSexual dysfunction TRANQUILIZERThe term TRANQUILIZERS: CLINICAL CLASSIFICATIONshort-acting(T½ 2-10 hours)Lorazepam Oxazepam Alprazolam (Xanax)With sedationlong-acting(T½ 20-60 hours)PhenazepamDiazepam Nitrazepamwith challengingEFFECT( TRANQUILIZERS: THERAPEUTIC EFFECTSanxiolyticmyorelaxationanticonvulsantHypnoticsedativeAntifobicvegetative stabilizingTRANQUILIZER TRANQUILIZERS TESTIMONY Neurotic disorders  Personality disorder in the period of decompensation  Withdrawal TRANQUILIZERS SIDE EFFECTSViolation of attention, memory, speed reduction reaction, coordination of movements.  Sleeping pills (Hypnotic)2 GENERATION- Benzodiazepines (oxazepam, nitrazepam)1 GENERATION- Barbiturates (phenobarbital contained in GENERAL PRINCIPLES OF DRUG THERAPY SLEEP DISORDERS:Application of the minimum effective doseShort MOOD STABILIZERSAnticonvulsantsCarbamazepine(Finlepsin, Tegretol)The salts of valproic acid(Depakine, Konvuleks)mineralsaltlithium preparations(Carbonate Li, Sedalia, Mical)mood stabilizers PSYCHOSTIMULANTSImprove mediator transmission at synapsesIt stimulates the central nervous system activityTake off PSYCHOSTIMULANTSCAFFEINESIDNOKARBSIDNOFENIncreased anxiety, fear  sleep disturbances  The dependenceIn case of overdose - to NOOTROPICSNootropics or stimulants neyrometabolitic - have a specific effect on the higher NOOTROPICSCLINICAL EFFECTSNootropic effect (effect on the higher cortical functions). Mnemotropnoe effect (effect on NOOTROPIL: TESTIMONYPsycho-organic syndrome and dementia of various origins  asthenic conditions  Chronic intoxication  suggestionHypnotherapyself-suggestionEmotional stressPlacebo-therapyCLASSIFICATION PSYCHOTHERAPEUTIC METHODSsuggestiveRATIONALPSYCHOTHERAPYPSYCHOANALYSISBehaviouralCLASSICAL METHODSPSYCHOTHERAPY is a system of complex therapeutic effects THANK YOU FOR ATTENTION
Слайды презентации

Слайд 2 TREATMENT OF MENTAL DISORDERS
Biological therapy
Psychotherapy
Social rehabilitation
Methods of

TREATMENT OF MENTAL DISORDERSBiological therapyPsychotherapySocial rehabilitation Methods of therapeutic effects on

therapeutic effects on biological processes
System of psychological methods

of therapeutic effects on the psyche

- a set of measures,
aimed at
maximum
adaptation
the mentally ill into society and
their restoration
professional
functioning.

OPTIONS


Слайд 3 HISTORY OF THERAPY Trepanation
Jan van Hemessen (Jan Sanders

HISTORY OF THERAPY TrepanationJan van Hemessen (Jan Sanders van Hemessen)?

van Hemessen)? "Removing the stones of stupidity." 1545-1550 gg.


Слайд 4 HISTORY OF THERAPY Straitjackets

HISTORY OF THERAPY Straitjackets

Слайд 5 HISTORY OF THERAPY 'Shock' methods
Electro-convulsive therapy (ECT)
The main

HISTORY OF THERAPY 'Shock' methodsElectro-convulsive therapy (ECT)The main indications:  resistant depression 

indications:
  resistant depression
  Catatonic syndrome
  resistant schizophrenia
Insulin shock

therapy - administration of increasing doses of insulin to the development of hypoglycemic com.
Indications: treatment-resistant schizophrenia.

Слайд 6 HISTORY OF THERAPY Neurosurgical treatment
LOBOTOMY
INDICATIONS:
resistant depression,
anxiety disorders,
aggressive behavior in

HISTORY OF THERAPY Neurosurgical treatmentLOBOTOMYINDICATIONS:resistant depression,anxiety disorders,aggressive behavior in patients with

patients with schizophrenia.
Stereotactic brain surgery
INDICATIONS:
brain tumor
epilepsy,
resistant depression,
obsessive-compulsive disorders,
addiction.


Слайд 7 DRUG THERAPY OF MENTAL DISORDERS
Psychotropic drugs are capable

DRUG THERAPY OF MENTAL DISORDERSPsychotropic drugs are capable of regulating disturbed

of regulating disturbed mental activity and are used to

treat mental illness.

a group of drugs that have a predominant influence on psychological processes.

PSYCHOTROPIC
(Psychopharmacological)
FACILITIES


Слайд 8 PSYCHOTROPIC DRUGS: CLASSIFICATION
ANTIPSYCHOTICS (NEUROLEPTICS)
ANTIDEPRESSANTS
ANTIPARKINSONIAN
MOOD STABILIZERS
PSYCH STIMULANTS
NOOTROPICS
ANTIEPILEPTIC
ANTIPARKINSONIAN
HYPNOTICS

PSYCHOTROPIC DRUGS: CLASSIFICATIONANTIPSYCHOTICS (NEUROLEPTICS)ANTIDEPRESSANTSANTIPARKINSONIANMOOD STABILIZERSPSYCH STIMULANTSNOOTROPICSANTIEPILEPTICANTIPARKINSONIANHYPNOTICS

Слайд 9 ANTIPSYCHOTICS
The main action - an antipsychotic (reduction of

ANTIPSYCHOTICSThe main action - an antipsychotic (reduction of delusions and hallucinations?)The

delusions and hallucinations?)
The first neuroleptic - chlorpromazine (chlorpromazine), which

is synthesized as an antihistamine in 1950; its efficacy has been found in 1952 year.

The main mechanism of action of antipsychotic drugs - a blockade of postsynaptic dopamine receptors.

CLASSIFICATION
TYPICAL ANTIPSYCHOTIC

MOSTLY WITH SEDATION

PREFERABLY WITH AN ANTIPSYCHOTIC ACTION


Слайд 10 HISTORY antipsychotics
Chlorpromazine
Risperidone
Haloperidol
Clozapine
Olanzapine
Quetiapine

1960
1970
1980
1990
2000
1950
Fluphenazine
Thioridazine
Jibson MD, Tandon R. J Psychiatr Res

HISTORY antipsychoticsChlorpromazineRisperidoneHaloperidolClozapineOlanzapineQuetiapine196019701980199020001950FluphenazineThioridazineJibson MD, Tandon R. J Psychiatr Res 1998;32:215–228;Lehmann HE, Ban

1998;32:215–228;
Lehmann HE, Ban TA. Can J Psychiatry 1997;42:152–162.
Ziprasidone
Традиционные нейролептики
Атипичные


антипсихотики

Слайд 11 CLASSIFICATION Antipsychotic
- Have fewer extrapyramidal disorders

Effectiveness at the

CLASSIFICATION Antipsychotic- Have fewer extrapyramidal disordersEffectiveness at the negative symptoms of

negative symptoms of schizophrenia

- They have minimal affinity for

dopamine receptor and block the serotonin

for example
Clozapine (azaleptin, leponeks) -
Risperidone (rispolept, speridan)
Olanzapine (Zyprexa)

ATYPICAL
Antipsychotics


Слайд 12
Do not induce extrapyramidal disorders
sedation
  the impact on

Do not induce extrapyramidal disorderssedation  the impact on the cardiovascular system 

the cardiovascular system
  no sex disorders
  prolactinemia
  weight gain
efficiency

in positive symptoms
  efficiency in negative symptoms
  efficiency resistant cases

FEATURE ATYPICAL ANTIPSYCHOTICS


Слайд 13 PROLONGED FORMS OF ANTIPSYCHOTICS
Specific dosage forms neuroleptics, which,

PROLONGED FORMS OF ANTIPSYCHOTICSSpecific dosage forms neuroleptics, which, after the /

after the / m is gradually released from the

depot in the muscle and blood have a therapeutic effect for a long time (up to 1 month)


Preparations:
Haloperidol decanoate
Klopiksol depot
Rispolept-Consta


Слайд 14 SIDE EFFECTS TYPICAL ANTIPSYCHOTICS
D2
Blockade of dopamine retseptrov:
antipsychotic effect.
hyperprolactinemia
negative symptoms
tarditivnaya

SIDE EFFECTS TYPICAL ANTIPSYCHOTICSD2Blockade of dopamine retseptrov:antipsychotic effect.hyperprolactinemianegative symptomstarditivnaya dyskinesiaAlpha1-adrenergic receptors

dyskinesia
Alpha1-adrenergic receptors - the blockade:
Lowering blood pressure
Dizziness
Drowsiness
Alpha 1
Н1
М1
H1-histamine receptors

- the blockade:
Weight gain
Drowsiness

M1 receptors - the blockade:
Constipation
Dry mouth
Drowsiness
The narrowing of visual fields

typical
antipsychotics


Слайд 15 SIDE EFFECTS ATYPICAL ANTIPSYCHOTICS
5НТ2А
D2
Atypical
antipsychotics
Serotonin 5HT2A
retseptory- blockade:
regulation of release
dopamine
Dopamine

SIDE EFFECTS ATYPICAL ANTIPSYCHOTICS5НТ2А D2AtypicalantipsychoticsSerotonin 5HT2Aretseptory- blockade:regulation of releasedopamineDopamine D2 receptors -blokantipsychotic effecthyperprolactinemianegative symptomstardive dyskinesia

D2 receptors -blok
antipsychotic effect
hyperprolactinemia
negative symptoms
tardive dyskinesia


Слайд 16 SYMPTOMS:
muscle rigidity
temperature rise
trophic changes
stupor.
MALIGNANT
neuroleptic syndrome
TREATMENT:
hospitalization in an

SYMPTOMS:muscle rigiditytemperature risetrophic changesstupor. MALIGNANTneuroleptic syndromeTREATMENT:hospitalization in an intensive care unitcancellation

intensive care unit
cancellation of neuroleptics
infusion therapy and so forth.
ADVERSE

EFFECTS
antipsychotics

A LIFE-THREATENING CONDITION OF THE PATIENT!


Слайд 17
The surgery - consisting of mixtures for artificial

The surgery - consisting of mixtures for artificial hypothermia (chlorpromazine).In anesthesiology

hypothermia (chlorpromazine).

In anesthesiology and resuscitation - leptoanalgesia (droperidol), as

part of some "political" mixtures.

In dermatology - for the treatment of neurodermatitis, itching dermatoses (Tisercinum, sonapaks, etaperazin).
 
In therapy - treatment of hiccups, nausea and vomiting due to inhibition of the vomiting center at the blockade of dopamine receptors (etaperazin).

USE OF NEUROLEPTICS IN MEDICAL PRACTICE


Слайд 18 ANTIDEPRESSANTS



ANTIDEPRESSANT
effects caused by antidepressants
PSYCHOGOGIC
SEDATIVE
TIMANALEPTIC
VEGETATIVE
STABILIZING
ANTIFOBIC
HYPNOTIC
HOLINOLITIC
ANXIOLYTIC

ANTIDEPRESSANTSANTIDEPRESSANTeffects caused by antidepressantsPSYCHOGOGICSEDATIVETIMANALEPTICVEGETATIVE STABILIZINGANTIFOBICHYPNOTICHOLINOLITICANXIOLYTIC

Слайд 19 CLASSIFICATION ANTIDEPRESSANTS
DEPENDING ON THE CLINICAL EFFECT

Amitriptyline

STIMULATING
EFFECT

ANXIOLYTIC

CLASSIFICATION ANTIDEPRESSANTS DEPENDING ON THE CLINICAL EFFECTAmitriptylineSTIMULATING EFFECTANXIOLYTIC EFFECTSEDATIVESEFFECTMIASERCitalopram (Cipramil)Sertraline (Zoloft)Paroxetine

EFFECT

SEDATIVES
EFFECT
MIASER
Citalopram (Cipramil)
Sertraline (Zoloft)

Paroxetine (Paxil)
Milnacipran (Ixel)
Venlafaxine (Velaksin)
Mirtazapine (Remeron)
Imipramine (imipramine)
Doxepin (Doxepin)
Agomelatine

(melitor)

Tianeptine (tianeptine)

BALANCED


Слайд 20 STH EFFECTS
TRICYCLIC ANTIDEPRESSANTS
Respiratory
system
Cardiovascular
system
Endocrine system
Urinary
system
Digestive
system
Dry mouth
Constipation. Hepatotoxic action
urinary

STH EFFECTS TRICYCLIC ANTIDEPRESSANTSRespiratorysystemCardiovascularsystemEndocrine systemUrinarysystemDigestivesystemDry mouthConstipation. Hepatotoxic actionurinary retentionSexual dysfunctionOrthostatic hypotensionproaritmogennoe effectasequenceReduced secretion of bronchial glands

retention
Sexual dysfunction
Orthostatic hypotension
proaritmogennoe effect
asequence
Reduced secretion of bronchial glands


Слайд 21 STH EFFECTS
SELECTIVE SEROTONIN REUPTAKE INHIBITOR
Endocrine system
Digestive
system
Weight loss
Reduced

STH EFFECTS SELECTIVE SEROTONIN REUPTAKE INHIBITOREndocrine systemDigestivesystemWeight lossReduced secretion of salivary glandsDiarrheaNauseaSexual dysfunction

secretion of salivary glands
Diarrhea
Nausea
Sexual dysfunction


Слайд 22 TRANQUILIZER
The term "tranquilizer" (from the Latin tranquille -.

TRANQUILIZERThe term

To do a calm, serene) introduced the American psychiatrist

C. Rush in 1810, naming them so designed wooden chair strait.

The main effect of tranquilizers
anxiolytic
tranquilizing

The first tranquilizers:
chlordiazepoxide - 1959,
diazepam - 1961.


Слайд 23 TRANQUILIZERS: CLINICAL CLASSIFICATION
short-acting
(T½ 2-10 hours)
Lorazepam
Oxazepam
Alprazolam (Xanax)
With

TRANQUILIZERS: CLINICAL CLASSIFICATIONshort-acting(T½ 2-10 hours)Lorazepam Oxazepam Alprazolam (Xanax)With sedationlong-acting(T½ 20-60 hours)PhenazepamDiazepam Nitrazepamwith challengingEFFECT(

sedation
long-acting
(T½ 20-60 hours)
Phenazepam
Diazepam
Nitrazepam
with challenging
EFFECT
("Day"
tranquilizers)
Tofisopam (Grandaxinum)
TRANQUILIZER


Слайд 24 TRANQUILIZERS: THERAPEUTIC EFFECTS
anxiolytic
myorelaxation
anticonvulsant
Hypnotic
sedative
Antifobic
vegetative stabilizing
TRANQUILIZER

TRANQUILIZERS: THERAPEUTIC EFFECTSanxiolyticmyorelaxationanticonvulsantHypnoticsedativeAntifobicvegetative stabilizingTRANQUILIZER

Слайд 25 TRANQUILIZERS TESTIMONY
Neurotic disorders

  Personality disorder in the

TRANQUILIZERS TESTIMONY Neurotic disorders  Personality disorder in the period of decompensation 

period of decompensation

  Withdrawal symptoms and metaalkogol psychosis (on

the background of detoxification therapy)

  Sleep disorders (oxazepam, nitrazepam)

  Spastic syndrome (clonazepam)

Слайд 26 TRANQUILIZERS
SIDE EFFECTS
Violation of attention, memory, speed reduction

TRANQUILIZERS SIDE EFFECTSViolation of attention, memory, speed reduction reaction, coordination of

reaction, coordination of movements.

  Drowsiness for drugs with a

sedative effect.

  Muscular weakness

  Formation of dependence - according to WHO recommendations tranquilizers therapy should not exceed 2 weeks!

Слайд 27 Sleeping pills
(Hypnotic)
2 GENERATION
- Benzodiazepines (oxazepam, nitrazepam)
1 GENERATION
-

Sleeping pills (Hypnotic)2 GENERATION- Benzodiazepines (oxazepam, nitrazepam)1 GENERATION- Barbiturates (phenobarbital contained

Barbiturates (phenobarbital contained in korvalola, valokordin?)
  - Antihistamines, drugs

containing bromine

3 Generation

Zolpidem (Ivadal) and zopiclone (imovan)
  quick effect, short duration of action, few side effects.


Слайд 28 GENERAL PRINCIPLES OF DRUG THERAPY SLEEP DISORDERS:
Application of

GENERAL PRINCIPLES OF DRUG THERAPY SLEEP DISORDERS:Application of the minimum effective

the minimum effective dose
Short courses (no more than 2-3

weeks)

Intermittent procedure (2-4 times per week)

Phasing-out


Слайд 29 MOOD STABILIZERS
Anticonvulsants
Carbamazepine
(Finlepsin, Tegretol)
The salts of valproic acid
(Depakine, Konvuleks)
mineral
salt
lithium

MOOD STABILIZERSAnticonvulsantsCarbamazepine(Finlepsin, Tegretol)The salts of valproic acid(Depakine, Konvuleks)mineralsaltlithium preparations(Carbonate Li, Sedalia, Mical)mood stabilizers

preparations
(Carbonate Li, Sedalia, Mical)
mood stabilizers


Слайд 30 PSYCHOSTIMULANTS
Improve mediator transmission at synapses
It stimulates the central

PSYCHOSTIMULANTSImprove mediator transmission at synapsesIt stimulates the central nervous system activityTake

nervous system activity
Take off drowsiness
Strengthen mental and physical performance

(briefly)
Improve the ability to concentrate

improve storage
Facilitate thinking and speech
Increases activity, vigor
Reduce the need for food
Reduce the need for sleep


Слайд 31 PSYCHOSTIMULANTS

CAFFEINE
SIDNOKARB
SIDNOFEN
Increased anxiety, fear

  sleep disturbances

  The dependence
In case

PSYCHOSTIMULANTSCAFFEINESIDNOKARBSIDNOFENIncreased anxiety, fear  sleep disturbances  The dependenceIn case of overdose -

of overdose - to the development of:
intoxication delirium,
mania,
depression
hyperkinesis
side effects


Слайд 32 NOOTROPICS
Nootropics or stimulants neyrometabolitic - have a specific

NOOTROPICSNootropics or stimulants neyrometabolitic - have a specific effect on the

effect on the higher integrative brain function, stimulate learning

and memory, im prove mental performance (efficiency) and increase resistance to brain damaging factors (stress tolerance), without the typical side effects of psychostimulants.

Слайд 33 NOOTROPICS
CLINICAL EFFECTS
Nootropic effect (effect on the higher cortical

NOOTROPICSCLINICAL EFFECTSNootropic effect (effect on the higher cortical functions). Mnemotropnoe effect (effect

functions).
 Mnemotropnoe effect (effect on memory, learning).
 Raising the level of

consciousness, mental clarity.
 Adaptogenic effect (effect on tolerance to various exogenous factors, including drugs, increasing the overall resistance of the organism to extreme factors).
 Antiastenic effects (effects on fatigue, weakness, exhaustion, mental and physical effects of fatigue).
 Psychoactive effects (impact on apathy, hypobulia, aspontannost poverty motives, mental inertia, psychomotor retardation).
 The antidepressant action.
 Sedation, reducing irritability and emotional excitability.
 Vegetative effects (effect on headache, dizziness).

Слайд 34 NOOTROPIL: TESTIMONY
Psycho-organic syndrome and dementia of various origins
 

NOOTROPIL: TESTIMONYPsycho-organic syndrome and dementia of various origins  asthenic conditions  Chronic

asthenic conditions
  Chronic intoxication
  Neurological diseases
  To improve mental

performance

In pediatric practice:
delayed speech and mental development,
mental retardation,
the effects of perinatal CNS,
cerebral palsy,
attention deficit disorder in children.

Side effects:
  sleep disorders,
  anxiety


Слайд 35 suggestion
Hypnotherapy
self-suggestion
Emotional stress
Placebo-therapy
CLASSIFICATION
PSYCHOTHERAPEUTIC METHODS
suggestive
RATIONAL
PSYCHOTHERAPY
PSYCHOANALYSIS
Behavioural
CLASSICAL METHODS
PSYCHOTHERAPY is a system

suggestionHypnotherapyself-suggestionEmotional stressPlacebo-therapyCLASSIFICATION PSYCHOTHERAPEUTIC METHODSsuggestiveRATIONALPSYCHOTHERAPYPSYCHOANALYSISBehaviouralCLASSICAL METHODSPSYCHOTHERAPY is a system of complex therapeutic

of complex therapeutic effects using psychological tools on the

patient's psyche

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