Презентация на тему And the 2015 nobel prize winners in chemistry are…

damaged DNA and protect genetic information at a molecular

level, Tomas Lindahl, Paul Modrich and Aziz Sancar were awarded the Nobel Prize in Chemistry for 2015

radiation, free radicals, and other potentially cancer-causing agents, the

Nobel selection committee explained in a statement. However, even without those external factors, a person’s genetic molecules are “inherently unstable,” they noted, with a genome experiencing thousands of random, spontaneous changes on a daily basis.

repair DNA is essentially the only thing keeping our

cells from breaking down into “complete chemical chaos,” the Nobel committee added.

physiological chemistry at University of Gothenburg, demonstrated that DNA

decayed at a rate that should have prevented the development of life on Earth. Because of this discovery, Lindahl went on to discover base excision repair, a mechanism that repairs genes when a nucleotide’s base becomes damaged, preventing DNA collapse.

by cells to repair damage done to DNA by

UV radiation, and discovered that people born with defects to this system could develop skin cancer.

correct errors that happen when DNA is replicated through

cell division with a mechanism known as mismatch repair.

did not interact with each other in their studies

that involve different mechanisms of DNA repair.

In a statement, the Royal Swedish Academy said that the research conducted by Lindahl, Sancar, and Modrich has “not only deepened our knowledge of how we function, but could also lead to the development of lifesaving treatments.” The trio of scientists will split a prize of eight million Swedish Krona, or approximately $970,000, for their efforts