Презентация на тему Холинергическая вазодилатация сосудов скелетных мышц

мелких сосудов скелетных мышц
Десимпатизация
Атропин

forearm blood flow response to severe mental stress in

humans
Individual records from two subjects during periods of severe mental stress. A, in a patient with a unilateral cervical sympathectomy, mental stress (hatched bar) evoked profound increases in forearm blood flow in the normal arm. These increases in forearm blood flow were absent in the sympathectomised forearm. B, a second subject was studied with normal innervation to both upper extremities. Atropine given selectively to one forearm blunted but did not eliminate the vasodilator responses to severe mental stress. Adapted from Blair et al. (1959).

изменением
метаболизма скелетных
мышц под действием ACh

кислота
АК-ООН - метаболиты АК
ПК - цГМФ-зависимая

протеинкиназа

АК-ООН

Активация
фосфорилазы

Облегчение
сокращения

Ng

холинергическую дилятацию.
Максимум - через 30-40 секунд.

Повышение содержания:

Na+ - активация Na+/K+-насоса
вследствие гликолиза

K+ - выход K+ из гладких
мышц артерий

Молочной кислоты - вследствие
гликолиза

Обладают
вазомоторной
активностью

stress in humans
Tracings of the forearm blood flow

responses to mental stress in an individual in which one forearm was treated with the NO synthase inhibitor L-NMMA via a brachial artery catheter. In the control arm, mental stress evoked marked skeletal muscle vasodilatation. This vasodilatation was absent in the arm treated with L-NMMA. These data indicated that NO is involved in the forearm vasodilator response to sympathoexcitatory manoeuvres in humans. From Dietz et al. (1994a).